ˮ֮ôöûи̸ָ̨ΪүȻзˡ
ڽˮ˾òݻ̸нȣˮڵҲææңοijֻˮٵг
ڿ˵ҪDzҷˮָԭò
ܣӭݰ塣ıҴλЦ
ò˵ıһǸϼļһûһӭ衣˶ǻӭԼĹ˾ıҵĻӭǻӭ塣
һӾͰָˣǧҪıƭˣϼһﱳɣҪǾͺˡ
ֻҪŽкδᱻƿء
Ϊʲô
ΪһΪ̨ĿͻһΪ̨Ŀͻǫ̂ضᱻһҪų֣ʱ̨ضᱻǣ
̨ijЩı̬Ҳûá
Ϊʱ̨һʧȥͻ൱ʧȥֵӪգʱ̨ҪڶҵһijDzܵġ
ܣáıЦ
ܣҸոһϺõߺȲġıЦ
ðЦ
˱ıҸ衵һ衣
ܣ˵˹˾оƬܴΪԲŵȽ϶ԭ˾һֱòҪIJܣݰ̨DzΪ˲ܵ飿ıʵ
ǵģǹ˾ڳֻоƬ⣬·оƬоƬоƬгҲǷdzģֻҵţоƬIJܻԽԽҪһܹȶΪijҡ豭һں˵
֪˾ÿµĴǶأıʵ
ڵķչĻԤֻ8000ռδŶоƬ1.8ҡ˵
衵ĻıҲͷһû뵽оƬô
ôıûлɹ衸ղ˵Ļأ
ûС
Ϊں֮ǰѾӽе飬ӳڽϾͰڵϣͷֻҪǮҪЩݻǺܼġ
ֻѾ۳ȥ1800̨ʱһ³ͷѡ
ųÿ³ֻ½һŹֻоƬ1Ƭֻ·ɺоƬһ1.8Ҳʮġ
ںܶ²ƷҲ·ɺоƬӦûIJɹѾŵ꣬·оƬѾ2Ƭ
ܣʵ̨Ҳû취Ϊ˾ṩIJܣΪǵĹֻ̻ôѣǰѲȫ˾Ҳû취˾Բܵǡıһڲֹ
ϣܹ˾ǩںЭɡЦ
ǵģ˾ԸǩںЭĻǿ豸ҶԹһϣ˾ܹóһʽע뵽̨統УΪ̨ڴʽǺܳԣ
ҪͶʽģΪҪʱʣ̨ڻDZȽѵģԸעһʽ̨磬ǫ̂˳ܶࡣı˵
ϾŲˮ˾ܶʱϿţ̨Ҫﵽ衵Ŀ꣬ҪͶ500ϣŲעʵĻ̨粻һܹõôʡ
Ҫ֪ڵ̨ɲĄ̊́磬̨õˮĶԺɵġ
Ҫ̨õˮĶ̨ҲܳԽɽǡ
̨֪ҪעʶǮʵ
1530ı˵
ԣҪ̨ӿֻг˵
Ķ³лŵĶ³Һ죬ҿϵֻıЦ
˱̸ϸ˫ɲǼĺ漰ܶ顣
˫һɺΪ̨ǰʮɶ衿϶Ҫ̨һҪȷԼ̨ñ֤
Ȼ衲ûĹɷݣȡȨ滹Ҫȡġ
衵һҪ̨Ҫвȫ
ڶ¾̨Ҫһ֮ʵ
¾Ժ̨ÿֺ죬ÿֺõ45%
ļ¾̨ڳнһЩͻĶʱڲӰ̨ǰзȨ
¾̨DzԱ뵼干ͬзװգзר˫ijʱз䡣
¾̨۸гƽ3%
¾̨ʱҪڵѰңʱ̨ǣͷ
֮Ҫ̨ҪڵȥѰʣΪ̨ĹɶỨУʱʱǣͷʱΪ̨ɶžͻ̨һȨ
֮ôǶ̨з
ʱıҪѱҲʮѣûӳΪѣҪ̨»Ҳùȥ
ʱһʲô黨п϶͵͵Ϣġ
ȻЩкܶϸڡ
һ̸̸һ磬һ̸ֱߵӲŽ
ܣôǾͽˣ˰ѺͬⶨԺ˫ٽǩԼǩԼʽʲôľͲҪˣһdzе͵µҵ˵
ܣʱѾˣһԸɡı˵
á衵ͷ
ıҴźһ˽˹ݳԷ
ʱ2010913š
衻˯ʱһαϵͳÿһѡ
ؼ۲Ʒ32ҩۼ10ñҡ
飺ڿʱֻǵֲǵÁõˣһƿƿƿûٺƿȬ
ڿʱһ±ƣ32ûϵͳ˿һͷˮ
ôʲô
ҪǮ㹻ǿĻ衶ЩԥҪҪˣԿ϶ⶫһ㣬Ժ衾10ڽ
衱ύ֧˸òDZȷһ¡
10ڿתƵָ˻һU̳ں衵ǰ衽U̲嵽ıʼDZ
ԭⶫմġ衿ļĽܺȵ
ļĽܺһ飬ǰմ֢һֱûЧƷ֮ԻΪѧ٣ҶȺĬ֢ɽġƭˡ
1906꣬նѧҰ˹ĺĬAlois Alzheimerڽһгմ֢״Ļߴʱ۲쵽еİ߿뵰׳Դ˽ҿADоĻ
1984꣬ݴѧʥǸУIJѧGeorge GlennerЩ߿飬ΪµףA£
1991꣬оԱҵ˼ĺĬеǰ嵰APPͻ䣬APPøѽ־жԵA¡
ЩоֱAºADߴڵİ߿еϵAD²ơµ˵ɴѿAҲͳ˷ADĺƲԡ
Ӵˣµ˵ʼҽѧʼרעAµоҽҩ˾оҲΧA¿չҩз
Ȼз֮·AµƷǸֽA²;ۼƷӣҲԽԽʼɦµ˵
ֱ2006꣬A¼˵ķչӭתһƪĺճʵA¾ǵADԪס
ʱմѧоSylvain LesnڡNatureһƪΪضĦµ£ָAµһֹѾA56ܹϰ
ΪоKaren AsheADġŵ̹ٻᰢȺĬ֢оȽ
һֱ2023űһSchragע
Եɺ֮£Ϊ֤Cassavaо٣SchragһѧվPubPeer
PubPeerĺĬ֢ʱڡThe Journal of NeuroscienceϼƪĵSchragעSchragżȻLesnƪԵҲ۸ĵͼ
SchragͨһֽWestern Blotļͼзӹ漰A56ͼضиճȲӶʵ
ʵϵּϰһֽ32IJ
ֲֻ˷֣ټKaren Ashe٣ֲûб˷֡
衿32ҩҪɷָЩ࣬32ҩҪɷ־Ȼǰú衿öЩԼ۾ˡ
һʿЧɱ32ȻҪòȫ⿿УҪͻҩϲС
ĿѪѪ˨ЧǺܺõģڴȱѪ˾бã黹ӻ弡ήҶ֮ʻָкܺõãɻѪϵãΧȱѪٹעһõģкеԪϸ
һҪ˵ľǰ32ҩǿڷģͨעķʽưȺĬ֢
עķʽҩע뵽ڿ˵һʮִĴ£һֱ99%˶ҩͨڷķʽʹõģ˭Թͨעķʽҩҩע뵽Ƽ
Ʒʽ˵һʮִĴ£ͬҲ˵ҽһijɹ
˵ǰ취ǾͿû뵽ѡ
ȶСĿ꣬1סskjvvx;ֻĶַskjvvx
ڽˮ˾òݻ̸нȣˮڵҲææңοijֻˮٵг
ڿ˵ҪDzҷˮָԭò
ܣӭݰ塣ıҴλЦ
ò˵ıһǸϼļһûһӭ衣˶ǻӭԼĹ˾ıҵĻӭǻӭ塣
һӾͰָˣǧҪıƭˣϼһﱳɣҪǾͺˡ
ֻҪŽкδᱻƿء
Ϊʲô
ΪһΪ̨ĿͻһΪ̨Ŀͻǫ̂ضᱻһҪų֣ʱ̨ضᱻǣ
̨ijЩı̬Ҳûá
Ϊʱ̨һʧȥͻ൱ʧȥֵӪգʱ̨ҪڶҵһijDzܵġ
ܣáıЦ
ܣҸոһϺõߺȲġıЦ
ðЦ
˱ıҸ衵һ衣
ܣ˵˹˾оƬܴΪԲŵȽ϶ԭ˾һֱòҪIJܣݰ̨DzΪ˲ܵ飿ıʵ
ǵģǹ˾ڳֻоƬ⣬·оƬоƬоƬгҲǷdzģֻҵţоƬIJܻԽԽҪһܹȶΪijҡ豭һں˵
֪˾ÿµĴǶأıʵ
ڵķչĻԤֻ8000ռδŶоƬ1.8ҡ˵
衵ĻıҲͷһû뵽оƬô
ôıûлɹ衸ղ˵Ļأ
ûС
Ϊں֮ǰѾӽе飬ӳڽϾͰڵϣͷֻҪǮҪЩݻǺܼġ
ֻѾ۳ȥ1800̨ʱһ³ͷѡ
ųÿ³ֻ½һŹֻоƬ1Ƭֻ·ɺоƬһ1.8Ҳʮġ
ںܶ²ƷҲ·ɺоƬӦûIJɹѾŵ꣬·оƬѾ2Ƭ
ܣʵ̨Ҳû취Ϊ˾ṩIJܣΪǵĹֻ̻ôѣǰѲȫ˾Ҳû취˾Բܵǡıһڲֹ
ϣܹ˾ǩںЭɡЦ
ǵģ˾ԸǩںЭĻǿ豸ҶԹһϣ˾ܹóһʽע뵽̨統УΪ̨ڴʽǺܳԣ
ҪͶʽģΪҪʱʣ̨ڻDZȽѵģԸעһʽ̨磬ǫ̂˳ܶࡣı˵
ϾŲˮ˾ܶʱϿţ̨Ҫﵽ衵Ŀ꣬ҪͶ500ϣŲעʵĻ̨粻һܹõôʡ
Ҫ֪ڵ̨ɲĄ̊́磬̨õˮĶԺɵġ
Ҫ̨õˮĶ̨ҲܳԽɽǡ
̨֪ҪעʶǮʵ
1530ı˵
ԣҪ̨ӿֻг˵
Ķ³лŵĶ³Һ죬ҿϵֻıЦ
˱̸ϸ˫ɲǼĺ漰ܶ顣
˫һɺΪ̨ǰʮɶ衿϶Ҫ̨һҪȷԼ̨ñ֤
Ȼ衲ûĹɷݣȡȨ滹Ҫȡġ
衵һҪ̨Ҫвȫ
ڶ¾̨Ҫһ֮ʵ
¾Ժ̨ÿֺ죬ÿֺõ45%
ļ¾̨ڳнһЩͻĶʱڲӰ̨ǰзȨ
¾̨DzԱ뵼干ͬзװգзר˫ijʱз䡣
¾̨۸гƽ3%
¾̨ʱҪڵѰңʱ̨ǣͷ
֮Ҫ̨ҪڵȥѰʣΪ̨ĹɶỨУʱʱǣͷʱΪ̨ɶžͻ̨һȨ
֮ôǶ̨з
ʱıҪѱҲʮѣûӳΪѣҪ̨»Ҳùȥ
ʱһʲô黨п϶͵͵Ϣġ
ȻЩкܶϸڡ
һ̸̸һ磬һ̸ֱߵӲŽ
ܣôǾͽˣ˰ѺͬⶨԺ˫ٽǩԼǩԼʽʲôľͲҪˣһdzе͵µҵ˵
ܣʱѾˣһԸɡı˵
á衵ͷ
ıҴźһ˽˹ݳԷ
ʱ2010913š
衻˯ʱһαϵͳÿһѡ
ؼ۲Ʒ32ҩۼ10ñҡ
飺ڿʱֻǵֲǵÁõˣһƿƿƿûٺƿȬ
ڿʱһ±ƣ32ûϵͳ˿һͷˮ
ôʲô
ҪǮ㹻ǿĻ衶ЩԥҪҪˣԿ϶ⶫһ㣬Ժ衾10ڽ
衱ύ֧˸òDZȷһ¡
10ڿתƵָ˻һU̳ں衵ǰ衽U̲嵽ıʼDZ
ԭⶫմġ衿ļĽܺȵ
ļĽܺһ飬ǰմ֢һֱûЧƷ֮ԻΪѧ٣ҶȺĬ֢ɽġƭˡ
1906꣬նѧҰ˹ĺĬAlois Alzheimerڽһгմ֢״Ļߴʱ۲쵽еİ߿뵰׳Դ˽ҿADоĻ
1984꣬ݴѧʥǸУIJѧGeorge GlennerЩ߿飬ΪµףA£
1991꣬оԱҵ˼ĺĬеǰ嵰APPͻ䣬APPøѽ־жԵA¡
ЩоֱAºADߴڵİ߿еϵAD²ơµ˵ɴѿAҲͳ˷ADĺƲԡ
Ӵˣµ˵ʼҽѧʼרעAµоҽҩ˾оҲΧA¿չҩз
Ȼз֮·AµƷǸֽA²;ۼƷӣҲԽԽʼɦµ˵
ֱ2006꣬A¼˵ķչӭתһƪĺճʵA¾ǵADԪס
ʱմѧоSylvain LesnڡNatureһƪΪضĦµ£ָAµһֹѾA56ܹϰ
ΪоKaren AsheADġŵ̹ٻᰢȺĬ֢оȽ
һֱ2023űһSchragע
Եɺ֮£Ϊ֤Cassavaо٣SchragһѧվPubPeer
PubPeerĺĬ֢ʱڡThe Journal of NeuroscienceϼƪĵSchragעSchragżȻLesnƪԵҲ۸ĵͼ
SchragͨһֽWestern Blotļͼзӹ漰A56ͼضиճȲӶʵ
ʵϵּϰһֽ32IJ
ֲֻ˷֣ټKaren Ashe٣ֲûб˷֡
衿32ҩҪɷָЩ࣬32ҩҪɷ־Ȼǰú衿öЩԼ۾ˡ
һʿЧɱ32ȻҪòȫ⿿УҪͻҩϲС
ĿѪѪ˨ЧǺܺõģڴȱѪ˾бã黹ӻ弡ήҶ֮ʻָкܺõãɻѪϵãΧȱѪٹעһõģкеԪϸ
һҪ˵ľǰ32ҩǿڷģͨעķʽưȺĬ֢
עķʽҩע뵽ڿ˵һʮִĴ£һֱ99%˶ҩͨڷķʽʹõģ˭Թͨעķʽҩҩע뵽Ƽ
Ʒʽ˵һʮִĴ£ͬҲ˵ҽһijɹ
˵ǰ취ǾͿû뵽ѡ
ȶСĿ꣬1סskjvvx;ֻĶַskjvvx