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һĿʮеɨAIļļĻĤͶĹߡ̫Ѩͻͻֱǻɬ⼴ʧЧǰסָʶĦۿﻹŰ÷ӡĺۼ
߸ЬߵԶij־ĵʱҲ̧ͷҲ֪ޱܰ˫ĺɫϸ߸ЬûʯĽྫԶװǹתдһֱɡ
إڰҹɤŸϢߣָͻȻҵĺޱܱȳ˵ȣ˿ȴȪů⣬˵ýЩ
üܿĴȫϢĻ̰ѪĻ̵ۡڰǩˡЭ顷Ԥɳƣﰺ˴ϢʥĸԺʴΧ
ޱƵǰżɫװ¶ǴѾʼֳͼԴӱ˵ʥۻԶѰµˡ
߶ʮͷбٵӰصһǵĻжôůǸ֮ǰܾãԼǰԷɣ㷸ϵŮ ¶ռϵŮѵȺá
ҵijٵԭ䰲ȣ࣬ޱޱȻеإ... ûŴڵԺѾҪ˲ҺˡҵϵŮȺޱĻԴ齫
ϵã͵ź£ࡣͰ͵ͰԼż˯ǾDzҼҵԼ̴ʡһС̫һޱ
ЩУģʲô˵ƺҲֻޱߣ̤ʵ÷˴Ĵ£뿪ңԭҡʲôϸµķһֱܵжϡָоȴСչҵǿҡ
½ҡʱ˿ɨֱѩķҰ۷ۣ㡪Ϳĸ̼͵ָͻȻβôȥҪˡ
͵غƤηظ֨ѽޱָڰգĸ̨̼Ĺ⣬ֵͫ۷ۡ
ͲͣҶǴֵĦʥۣǰ˵ȱʱޱǿɲµӡǡ˿ʥ𣬷·ںӦijңԶٻ
ޱͻȻϥͷװȹڻȸ¶ɫ˿Сȡ̻ɫ˿˿࣬һضʸУͬҹıĺ̡˿ϸ£˿˿ƽ֯ͼڹߵӳ˸Ĺ·ϸ˿߹ճλû
СǹϣܼҾĵƷ˿żճСȼÿһȶǡô鶯šļ˿ķ϶¹ѩϣʥࡣǰ̻ɫ˿γĶԱȣǿȴֺгļͬ覵ϸ壬̻ɫij£ԵþӨ·ơ̻ɫ˿ΪһĨȻСȿŮĴ棬ִһֳԸС
ؿɫѪܣͬѵϪΪļ˼ĽϸСɣðɣ̻ɫ˿ڽ״սԳӯӯһյϸĽֺ˿˶·˵ijջҸоԼĿDZʯ˫̻ɫ˿˿Сƿӿһļ¶ָҺķңָǡѹҷӡٵķϣ£ұĺŸϢһ˿𣬡ϾҺѪ
ʲô˵ʲôսҺͰȼʱΪУһֱϸҵգһֱŰհаôھȻ... Ȼ˵Һĺӣ˵裬Ҷš
ЦָͻȻƷɬˮӿۿճɫĺۼУ˸߿ǰѧʦ𣿡
糱ˮӿ꣬ҵѧɼβڷѧҵΡܴɫְҵװ¶ǴԺѸٸֳģһżȧǸ߸ͻͻأʯͷһ˫۾ϸϸβϵһɾľϬ÷·ܿģֻҪĿһɨҾ;ԼDZǹ·еС˼Ρıϸͦͷ̣һģ촽˵ټ죬һһףǹɨһ㣬˺м֮
꣬ÿұΣﶼΡµͬĸʨӰģÿʱܴҵǽڣÿһֶʹҵģεԼѧʵ̫ѧԹʧĺӣôҲҲڡɼˣǶʱȴҲűĻ䡣
һΣһôⲻȹϵץһƨԱߣüͷˡ֣ԭͼݵΪżǵͨ죬˵ķѡ˫ֲ߶ţ⺢ӣô˼·벻DZס𣡡˵ţһָشĿڲݸֽϷɿддϵϸŶζ졣ķ˿Щҵɢԣ¶ڻƵĵƹ¾ԵЩͣһֱջ̲ס͵͵Ƴ˼ۡ
һأΪԳɼ̫ɥֻܵĹλԴ߹žһҵļȻǸȴִżֱģȴѵõºͣ٣̫ģ϶ߡһ̣ûƽϬ˼̶ֹͬˮС
һδεٺĽ̵£ҵѧɼɫǶκһڷѧĽΪһѧ۲ݣ˫ֲģΪһСȸԾʱǿĵӰЦݣɬĹӣһ˿ɬȴҲഺζ
ҵԱͬ꣬һżȻͬѧۻᣬּƹľưôָʹʲôۻΪѧȵļֿңҾôǸŮ˿˺þãȻʹߵһһУͬһضҵΣӡҵĵסޱЩ³Ļ䣬ͬˮ㽫ҽΧ
ҿޱ̫ˣôأȻԴ֪𣬾֪DZε.... ̫ˣ֣ôأ˵ԼİDZˣڴХʱ.... ˵˶ɵˡ
ҺͰڽְDzڱˣҺͰȿûΰץҵʱôΰĸ֪ģ
һʼƺͶе⣬ʱֻǸŰȡѵǰޱУԣԣҪֻƶֻ꣬ڼ£Żζ꣬Զ갡ǸʵijСӰѵˣֹһˣ
Ҽѵ˿ĭͷĹһ£Ų˼˵:... ǸޱҲDz㡣ֻ... ֻеҪʱҸæֵűӣҾһ䡣ҺͰȼʱ֪𣿡
ޱһЦǰϵģֻЦ˵:еʱֽѧֽѧҽ㳣ʶûУҿ㣬Ϊʲô½ﶼиӵļϵͳ
˵ԴԲɷ֣ҲEndogenous Viral Elements,߽ EVEs˵һЩEVEsת¼RNAһֻڲ鶯ijЩķǸӵԪǽ
ޱͫɴֱϸ죬Ĥ渡ֳе״Ρ"Ļ༭ӦԴת¼Ȼ"ҵưԼƤٲŷĽɣ"ǵҸȵķˮΪijַζҩ
ľԭϸֲHERV-KǺӵĶԭҲζ걦ģϧκ鶼ԡǵĺǺζ꣬壬ȴûôǿϢءǶαĸļûҸģΪһָƷɡ"
һʱģ̲סʵ:ȵȣHERV-KͨΪDZѵζ⣿ҼǵCRISPR-Cas9ҲȻγɵİô£
λһġʦЦŽ͵:HERV-Kenv鳤غбǵ2016꡶Natureƪںϰص"ָпָø¶"ҲǸЩʯװ϶档CRISPRϵͳȷʵҪ˹ԤϸȻӦԡ"ޱչĤ¶γɵĤҼǵޱ˵۷۹žType III CRISPR/Casϵͳ"ҴȪȡCas10壬ͬʱʵDNAкͻźŴ"
ðɣðɣôǸɵӣһΪԼ˸˵ĺӡ... ưˡҼԼĺӡ
HERV-KϵͳԿһ֮ʹҺµijǿֲ£ΨһһҴ˰ɡ
ȶСĿ꣬1סskjvvx;ֻĶַskjvvx
һĿʮеɨAIļļĻĤͶĹߡ̫Ѩͻͻֱǻɬ⼴ʧЧǰסָʶĦۿﻹŰ÷ӡĺۼ
߸ЬߵԶij־ĵʱҲ̧ͷҲ֪ޱܰ˫ĺɫϸ߸ЬûʯĽྫԶװǹתдһֱɡ
إڰҹɤŸϢߣָͻȻҵĺޱܱȳ˵ȣ˿ȴȪů⣬˵ýЩ
üܿĴȫϢĻ̰ѪĻ̵ۡڰǩˡЭ顷Ԥɳƣﰺ˴ϢʥĸԺʴΧ
ޱƵǰżɫװ¶ǴѾʼֳͼԴӱ˵ʥۻԶѰµˡ
߶ʮͷбٵӰصһǵĻжôůǸ֮ǰܾãԼǰԷɣ㷸ϵŮ ¶ռϵŮѵȺá
ҵijٵԭ䰲ȣ࣬ޱޱȻеإ... ûŴڵԺѾҪ˲ҺˡҵϵŮȺޱĻԴ齫
ϵã͵ź£ࡣͰ͵ͰԼż˯ǾDzҼҵԼ̴ʡһС̫һޱ
ЩУģʲô˵ƺҲֻޱߣ̤ʵ÷˴Ĵ£뿪ңԭҡʲôϸµķһֱܵжϡָоȴСչҵǿҡ
½ҡʱ˿ɨֱѩķҰ۷ۣ㡪Ϳĸ̼͵ָͻȻβôȥҪˡ
͵غƤηظ֨ѽޱָڰգĸ̨̼Ĺ⣬ֵͫ۷ۡ
ͲͣҶǴֵĦʥۣǰ˵ȱʱޱǿɲµӡǡ˿ʥ𣬷·ںӦijңԶٻ
ޱͻȻϥͷװȹڻȸ¶ɫ˿Сȡ̻ɫ˿˿࣬һضʸУͬҹıĺ̡˿ϸ£˿˿ƽ֯ͼڹߵӳ˸Ĺ·ϸ˿߹ճλû
СǹϣܼҾĵƷ˿żճСȼÿһȶǡô鶯šļ˿ķ϶¹ѩϣʥࡣǰ̻ɫ˿γĶԱȣǿȴֺгļͬ覵ϸ壬̻ɫij£ԵþӨ·ơ̻ɫ˿ΪһĨȻСȿŮĴ棬ִһֳԸС
ؿɫѪܣͬѵϪΪļ˼ĽϸСɣðɣ̻ɫ˿ڽ״սԳӯӯһյϸĽֺ˿˶·˵ijջҸоԼĿDZʯ˫̻ɫ˿˿Сƿӿһļ¶ָҺķңָǡѹҷӡٵķϣ£ұĺŸϢһ˿𣬡ϾҺѪ
ʲô˵ʲôսҺͰȼʱΪУһֱϸҵգһֱŰհаôھȻ... Ȼ˵Һĺӣ˵裬Ҷš
ЦָͻȻƷɬˮӿۿճɫĺۼУ˸߿ǰѧʦ𣿡
糱ˮӿ꣬ҵѧɼβڷѧҵΡܴɫְҵװ¶ǴԺѸٸֳģһżȧǸ߸ͻͻأʯͷһ˫۾ϸϸβϵһɾľϬ÷·ܿģֻҪĿһɨҾ;ԼDZǹ·еС˼Ρıϸͦͷ̣һģ촽˵ټ죬һһףǹɨһ㣬˺м֮
꣬ÿұΣﶼΡµͬĸʨӰģÿʱܴҵǽڣÿһֶʹҵģεԼѧʵ̫ѧԹʧĺӣôҲҲڡɼˣǶʱȴҲűĻ䡣
һΣһôⲻȹϵץһƨԱߣüͷˡ֣ԭͼݵΪżǵͨ죬˵ķѡ˫ֲ߶ţ⺢ӣô˼·벻DZס𣡡˵ţһָشĿڲݸֽϷɿддϵϸŶζ졣ķ˿Щҵɢԣ¶ڻƵĵƹ¾ԵЩͣһֱջ̲ס͵͵Ƴ˼ۡ
һأΪԳɼ̫ɥֻܵĹλԴ߹žһҵļȻǸȴִżֱģȴѵõºͣ٣̫ģ϶ߡһ̣ûƽϬ˼̶ֹͬˮС
һδεٺĽ̵£ҵѧɼɫǶκһڷѧĽΪһѧ۲ݣ˫ֲģΪһСȸԾʱǿĵӰЦݣɬĹӣһ˿ɬȴҲഺζ
ҵԱͬ꣬һżȻͬѧۻᣬּƹľưôָʹʲôۻΪѧȵļֿңҾôǸŮ˿˺þãȻʹߵһһУͬһضҵΣӡҵĵסޱЩ³Ļ䣬ͬˮ㽫ҽΧ
ҿޱ̫ˣôأȻԴ֪𣬾֪DZε.... ̫ˣ֣ôأ˵ԼİDZˣڴХʱ.... ˵˶ɵˡ
ҺͰڽְDzڱˣҺͰȿûΰץҵʱôΰĸ֪ģ
һʼƺͶе⣬ʱֻǸŰȡѵǰޱУԣԣҪֻƶֻ꣬ڼ£Żζ꣬Զ갡ǸʵijСӰѵˣֹһˣ
Ҽѵ˿ĭͷĹһ£Ų˼˵:... ǸޱҲDz㡣ֻ... ֻеҪʱҸæֵűӣҾһ䡣ҺͰȼʱ֪𣿡
ޱһЦǰϵģֻЦ˵:еʱֽѧֽѧҽ㳣ʶûУҿ㣬Ϊʲô½ﶼиӵļϵͳ
˵ԴԲɷ֣ҲEndogenous Viral Elements,߽ EVEs˵һЩEVEsת¼RNAһֻڲ鶯ijЩķǸӵԪǽ
ޱͫɴֱϸ죬Ĥ渡ֳе״Ρ"Ļ༭ӦԴת¼Ȼ"ҵưԼƤٲŷĽɣ"ǵҸȵķˮΪijַζҩ
ľԭϸֲHERV-KǺӵĶԭҲζ걦ģϧκ鶼ԡǵĺǺζ꣬壬ȴûôǿϢءǶαĸļûҸģΪһָƷɡ"
һʱģ̲סʵ:ȵȣHERV-KͨΪDZѵζ⣿ҼǵCRISPR-Cas9ҲȻγɵİô£
λһġʦЦŽ͵:HERV-Kenv鳤غбǵ2016꡶Natureƪںϰص"ָпָø¶"ҲǸЩʯװ϶档CRISPRϵͳȷʵҪ˹ԤϸȻӦԡ"ޱչĤ¶γɵĤҼǵޱ˵۷۹žType III CRISPR/Casϵͳ"ҴȪȡCas10壬ͬʱʵDNAкͻźŴ"
ðɣðɣôǸɵӣһΪԼ˸˵ĺӡ... ưˡҼԼĺӡ
HERV-KϵͳԿһ֮ʹҺµijǿֲ£ΨһһҴ˰ɡ
ȶСĿ꣬1סskjvvx;ֻĶַskjvvx